The Influence of ABO and RhD Blood Groups on Platelet Storage Lesions in Refrigerated Whole Blood: A Longitudinal Analysis from Zliten Teaching Hospital
الشريط الجانبي للمقالة
محتوى المقالة الرئيسي
الملخص
Background: Platelet Storage Lesion (PSL) represents a critical challenge in transfusion medicine, characterized by structural and metabolic deterioration of platelets during storage.
Objective: This longitudinal study evaluated the progression of PSL in refrigerated whole blood (2–6°C) and analyzed its correlation with donor ABO/Rh blood group phenotypes.
Methods: Eighty whole blood units (n = 10 per ABO/Rh group) were monitored over a 30-day storage period. Platelet count (PLT) and Mean Platelet Volume (MPV) were measured using the Dymind 50 DF automated hematology analyzer at days 1, 10, 20, and 30. Statistical analyses included Repeated Measures ANOVA and One-Way ANOVA with Tukey's post-hoc test.
Results: Significant quantitative and morphological shifts were observed across all cohorts (P < 0.001). Group A+ demonstrated superior stability (34.0% PLT decline, 8.7% MPV increase), while Group O+ exhibited the most accelerated degradation (40.3% PLT decline, 12.6% MPV increase). Rh-negative variants consistently showed greater deterioration than their Rh-positive counterparts within the same ABO group.
Conclusion: ABO/Rh blood group antigens significantly modulate platelet resilience during refrigerated storage, suggesting that donor antigenic profiles should be considered a critical factor in blood inventory management strategies.
تفاصيل المقالة
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المراجع
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