Antifungal susceptibility testing of Malva parviflora yield extracts, against C. albicans and A. fumigatus

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Published: Jan 28, 2023
DOI: https://doi.org/10.64095/ajst.v1i1.42
Keywords:
Malva parviflora extracts, C. albicans, A. fumigatus, Antifungal

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Bushra Dakhil
Department of Microbiology and Immunology, University of Tripoli, Faculty of Pharmacy, Tripoli Libya
Ahmed Eshwika
Microbiology Department, Pharmacy College, University of Zawia, Zawia Libya
Basma Doro
Department of Microbiology and Immunology, University of Tripoli, Faculty of Pharmacy, Tripoli Libya
Rabia O Alghazeer
Chemistry Department, Faculty of Science, University of Tripoli
Ibrahim Eldaghayes
Department of Microbiology and Parasitology, Faculty of Veterinary Medicine
Keven kavanagh
Medical Mycology Unit, Biology Department, Maynooth University, Co Kildare, Ireland

Abstract

The increasing on the incidence of drug-resistant pathogens has drawn the attention of
researchers towards screening the antimicrobial action of plant-derived compound. This
study aimed to determine the antifungal activity of Malva parviflora extracts, which is
widespread and used by the general population in Libya. Extraction was carried out using a
cold maceration method by several different polarity solvents (petroleum ether, ethyl
acetate, methanol and distilled water). Their total-phenolic and flavonoid content were
assessed. The content of total phenolic and flavonoids were found to be the highest in
petroleum ether fraction extract (119.558mg GAEg-1) and (227.029mg RU g-1)
respectively. The antioxidant activity was estimated using DPPH as free radical scavenging
and sugar reducing power. The methanol fraction extract displayed the highest IC50 (50
mg/ml). The results indicate that the increase in the percentage of DPPH free radical
inhibition is directly proportional with the increase in the extract concentration. Reducing
power increased with the increase on extracts concentration. M. parviflora leave extracts
were tested against fungal species Aspergillus. fumigatus and Candida. albicans using
antifungal susceptibility assay of yeast and filamentous fungi. Extracts had strong
antifungal activity against C. albicans and A. fumigates. Petroleum ether fraction extract
has the strongest antifungal activity against A. fumigatus with 94.96% percentage of
inhibition. The percentage of inhibition is 96.48% was shown against C. albicans for
aqueous extract.

Article Details

How to Cite
Dakhil, B., Eshwika, A., Doro, B., Alghazeer, R. O., Eldaghayes, I., & kavanagh, K. (2023). Antifungal susceptibility testing of Malva parviflora yield extracts, against C. albicans and A. fumigatus. Academic Journal of Science and Technology, 1(1), 101–108. https://doi.org/10.64095/ajst.v1i1.42
Issue
Vol. 1 No. 1 (2023): Academic Journal of Science and Technology
Section
Biomedical sciences

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